Heredity beyond the gene
نویسندگان
چکیده
منابع مشابه
The Allusion of the Gene: Misunderstandings of the Concepts Heredity and Gene
Life sciences became Biology, a formal scientific discipline, at the turn of the nineteenth century, when it adopted the methods of reductive physics and chemistry. Mendel’s hypothesis of inheritance of discrete factors further introduced a quantitative reductionist dimension into biology. In 1910 Johannsen differentiated between the phenotype, which defines traits, and their genotype, the here...
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James Mark Baldwin is remembered today almost exclusively for his paper ‘A New Factor in Evolution’ (Baldwin, 1896a). The new factor, which he called ‘organic selection’ and which later became known as the Baldwin effect, was a process that could cause ‘accomodations’ the acquired adaptive responses of individual organisms to become hereditary. ‘Accomodations’ include physiological adaptations ...
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This paper is a response to the increasing difficulty biologists find in agreeing upon a definition of the gene, and indeed, the increasing disarray in which that concept finds itself. After briefly reviewing these problems, we propose an alternative to both the concept and the word gene-an alternative that, like the gene, is intended to capture the essence of inheritance, but which is both ric...
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The Fanconi anemia (FA)/BRCA pathway consists of fifteen proteins that mediate DNA homologous recombination (HR) and promote chromosomal stability. Here we review the evidence that genetic and epigenetic alterations in BRCA2 (FANCD1), BRIP1 (FANCJ), FANCD2, FANCF, PALB2 (FANCN) and RAD51C (FANCO), render ovarian cells susceptible to malignant transformation. In addition, we discuss the paradoxi...
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The blood was obtained from the finger and collected in small test tubes, using as an anticoagulant one drop of 3.8 percent dihydnc sodium citrate for every ten drops of blood. Two percent suspensions of the red cell sediments in saline solution were prepared, and the A , B groups and M , N types were determined. The tests for these agglutinogens were carried out on Boerner well slides, one dro...
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ژورنال
عنوان ژورنال: Nature
سال: 2018
ISSN: 0028-0836,1476-4687
DOI: 10.1038/d41586-018-05211-z